Antibodies Are The Secreted Form Of B-lymphocyte Receptors And Are A Part Of Adaptive Immunity, But How

Antibodies are the secreted form of B-lymphocyte receptors and are a part of adaptive immunity, but how are these proteins formed?

Above is a diagram illustrating Paul Ehlrich’s Side Chain Theory of Antibody Formation. Ehlrich proposed that immunoglobulin molecules, a fundamental component of adaptive immunity, served as membrane bound proteins that bound to particular threats, similarly to the former “key in lock” view of enzymes in catalyzing biological reactions. Ehrlich also suggested that the action of binding a pathogenic molecule to the receptor would generate a signal to stimulate the production of more receptors of the same specificity. These “side chains” that were added on would then break off from the cell surface and become what we call antibodies.

We now know, however, that soluble immunoglobulin receptors are specially manufactured to be secreted as antibody, rather than just “breaking off” of the lymphocyte, even though they have the same specificity as their membrane-bound counterparts.

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thatwasnotveryravenofyou → itisextremelypigeonofthem

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tbh natural selection would've crushed bitches who couldn't see the spectrum fire is in

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we-are-all-paranoid

3 years ago

*sticks my hand in your nucleus and swirls your dna around*

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we-are-all-paranoid

7 months ago

A colored line drawing of Tetracynodon, an extinct relative of early mammals, in a sitting pose. It has a somewhat badger-like body covered in short fur, with fairly slender limbs ending in paws with long claws. Its head resembles a long-snouted lizard with large eyes. It's depicted with brown-and-tan coloration.

Therocephalians were a group of synapsids very closely related to – or possibly even ancestral to – the lineage leading to modern mammals. They were a diverse and successful group of carnivores during the latter half of the Permian, but suffered massively during the "Great Dying" mass extinction, with only a handful of representatives making it a few million years into the Triassic.

Tetracynodon darti was one of these rare Triassic therocephalian survivors, living in what is now South Africa around 251 million years ago. Only about 25cm long (~10"), it had slender limbs and strong claws that suggest it was a scratch-digger. Its long snout was lined with pointed teeth, and it was probably an active predator hunting by snapping its jaws at fast-moving prey like insects and smaller vertebrates.

Its combination of small size, burrow-digging habits, and unspecialized diet may be the reason it scraped through the Great Dying when most of its relatives didn't – but unfortunately it seems to have been a "dead clade walking", disappearing only a short way into early Triassic deposits.

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References:

Fontanarrosa, Gabriela, et al. "The manus of Tetracynodon (Therapsida: Therocephalia) provides evidence for survival strategies following the Permo-Triassic extinction." Journal of Vertebrate Paleontology 38.4 (2018): 1-13. https://doi.org/10.1080/02724634.2018.1491404

Sigurdsen, Trond, et al. "Reassessment of the morphology and paleobiology of the therocephalian Tetracynodon darti (Therapsida), and the phylogenetic relationships of Baurioidea." Journal of Vertebrate Paleontology 32.5 (2012): 1113-1134. https://www.researchgate.net/publication/254315180_Reassessment_of_the_Morphology_and_Paleobiology_of_the_Therocephalian_Tetracynodon_Darti_Therapsida_And_The_Phylogenetic_Relationships_of_Baurioidea

Wikipedia contributors. “Tetracynodon” Wikipedia, 21 Aug. 2024, https://en.wikipedia.org/wiki/Tetracynodon

Wikipedia contributors. “Therocephalia” Wikipedia, 01 Oct. 2024, https://en.wikipedia.org/wiki/Therocephalia

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we-are-all-paranoid

3 years ago

Not to self diagnose but something is wrong

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we-are-all-paranoid

3 years ago

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we-are-all-paranoid

3 years ago

Stop the ban on blood donation of gay men

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we-are-all-paranoid

3 years ago

biologists will be like this is a very simplified diagram of a mammalian cell

chemists will be like this is a molecule

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we-are-all-paranoid

7 months ago

Hey... what the fuck???

So I read the article, and this is super cool. Basically what happened is that they let a drop of butyl alcohol out from a syringe onto the surface of another liquid, and it just... hung out there? For a very significant amount of time, too. In the past, this type of "droplet levitation" has only lasted a few milliseconds max, but this droplet was staying levitated without any external forces applied for tens of minutes.

The reason this happens is because of Solutocapilllary convection, which as far as I can tell essentially boosts the surface tension of that one spot in the underlying liquid using vapor molecules, so that the butyl alcohol molecule can't sink in.

Also, the reason why I specified that the reason this was cool is because it was done without external forces is that APPARENTLY we've been able to levitate things using sound waves since like... the 1930s. And it makes sense that you can do that, in principle, but it still looks absolutely wild to see.