There’s Evidence Of A New Ninth Planet. For Real!

Newly discovered windows of brain plasticity may help with treatment of stress-related disorders

Chronic stress can lead to changes in neural circuitry that leave the brain trapped in states of anxiety and depression. But even under repeated stress, brief opportunities for recovery can open up, according to new research at The Rockefeller University.

(Image caption: Routine versus disruptive: A familiar stressor (left) did not increase NMDA receptors (dark spots), a booster of potentially harmful glutamate signaling, in the brains of mice. However, when subjected to an unfamiliar stress (right), mice expressed more NMDA receptors)

“Even after a long period of chronic stress, the brain retains the ability to change and adapt. In experiments with mice, we discovered the mechanism that alters expression of key glutamate-controlling genes to make windows of stress-related neuroplasticity—and potential recovery—possible,” says senior author Bruce McEwen, Alfred E. Mirsky Professor, and head of the Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology. Glutamate is a chemical signal implicated in stress-related disorders, including depression.

“This sensitive window could provide an opportunity for treatment, when the brain is most responsive to efforts to restore neural circuitry in the affected areas,” he adds.

The team, including McEwen and first author Carla Nasca, wanted to know how a history of stress could alter the brain’s response to further stress. To find out, they accustomed mice to a daily experience they dislike, confinement in a small space for a short period. On the 22nd day, they introduced some of those mice to a new stressor; others received the now-familiar confinement.

Then, the researchers tested both groups for anxiety- or depression-like behaviors. A telling split emerged: Mice tested shortly after the receiving the familiar stressor showed fewer of those behaviors; meanwhile those given the unfamiliar stressor, displayed more. The difference was transitory, however; by 24 hours after the final stressor, the behavioral improvements seen in half of the mice had disappeared.

Molecular analyses revealed a parallel fluctuation in a part of the hippocampus, a brain region involved in the stress response. A key molecule, mGlu2, which tamps down the release of the neurotransmitter glutamate, increased temporarily in mice subjected to the familiar confinement stress. Meanwhile, a molecular glutamate booster, NMDA, increased in other mice that experienced the unfamiliar stressor. In stress-related disorders, excessive glutamate causes harmful structural changes in the brain.

The researchers also identified the molecule regulating the regulator, an enzyme called P300. By adding chemical groups to proteins known as histones, which give support and structure to DNA, P300 increases expression of mGlu2, they found.

In other experiments, they looked at mice genetically engineered to carry a genetic variant associated with development of depression and other stress-related disorders in humans, and present in 33 percent of the population.

“Here again, in experiments relevant to humans, we saw the same window of plasticity, with the same up-then-down fluctuations in mGlu2 and P300 in the hippocampus,” Nasca says. “This result suggests we can take advantage of these windows of plasticity through treatments, including the next generation of drugs, such as acetyl carnitine, that target mGlu2—not to ‘roll back the clock’ but rather to change the trajectory of such brain plasticity toward more positive directions.”

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Israeli scientists see breakthrough in AIDS cure

Drug now being tested causes HIV-infected cells to self-destruct without harming the rest of the body

Israeli scientists see breakthrough in AIDS cure

Drug now being tested causes HIV-infected cells to self-destruct without harming the rest of the body

BY

TIMES OF ISRAEL STAFF

November 1, 2016, 3:26 am

HIV and AIDS patients may find new hope in a drug developed at Hebrew University in Jerusalem which is currently being tested at the Kaplan Medical Center in Rehovot.

The drug was inserted into test tubes containing the blood of ten AIDS patients currently being treated at the hospital, and was found to decrease the HIV virus count in the blood samples by as much as 97 percent in just eight days, Channel 2 reported Monday.

The active ingredient in the drug is a peptide, or smaller version of a protein, that was developed by Abraham Loyter and Assaf Friedler at Hebrew University. The peptide causes several copies of the virus’s DNA to enter the infected cell, instead of just one copy, causing the cell to self-destruct.

HIV is currently treated with a cocktail of drugs that slow the progression of the infection in the body but never rid the patient of the virus entirely. These drugs have allowed doctors to treat AIDS as a chronic illness as opposed to a fatal one.

Loyter explained that the new approach is superior to previous efforts.

“With our approach,” Loyter told Channel 2, “we are destroying the cells, so there is no chance that the virus will awaken one day, because there are no cells, there will be no cells that contain the virus.”

Loyter explained that “the drug enhances certain processes in the body during the spreading of the virus and that enhancement kills certain cells.”

In a separate but related development, the Health Ministry announced last week it would begin distributing prophylactic drugs for the first time to populations at higher risk of contracting HIV. The drugs, when taken regularly, have been found to be effective in preventing the spread of HIV during contact.

Friday, Cassini will dive into Saturn’s atmosphere and put an end to its nearly 20 year mission. Over those years we learned an incredible amount of information about Saturn, its rings, and its many moons. During the grand finale, Cassini will continue to send back information about Saturns atmosphere before burning up like a shooting star.

How To Build A Brain

My kid is playing a paper piano. I think I might be more wowed than anyone else in my house.

Besides the nerdy factor of circuit completion and conductivity of graphite… It’s just kind of kickass that a paper piano that I drew can work just like a real one with minimal effort AND my kids can play it way easier than a real piano.

Beyond "Mama" and "Dada": Why Babies Learn Certain Words

Babies learn different types of words first depending on their native language

English-speaking parents tend to use vague, one-size-fits-all verbs as they emphasize nouns: cars, trucks, buses, bicycles and scooters all simply “go.” Mandarin speakers do the opposite: they use catchall nouns such as “vehicle” but describe action—driving, riding, sitting on, pushing—with very specific verbs. “As a native English speaker, my first instinct when a baby points is to label,” Tardif says. Her babysitter, on the other hand, was a native Mandarin speaker, whose instinct was to name the action she thought the child was trying to achieve.

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Drone with grabbing claw arms can lift 44 pounds

Prodrone’s latest creation could lift a four-year-old child, and uses its 5-axis metal claws to perch on fences like a bird.