This Is So Cool! And It’s Already Great At Giving Me Ideas For Some Stories! Thank You So Much!

The link between drawing and seeing in the brain

Drawing an object and naming it engages the brain in similar ways, according to research recently published in JNeurosci. The finding demonstrates the importance of the visual processing system for producing drawings of an object.

(Image caption: Brain activation patterns during object recognition and production. Credit: Fan et al., JNeurosci 2019)

In a study by Fan et al., healthy adults performed two tasks while the researchers recorded brain activity using functional magnetic resonance imaging: they identified pieces of furniture in pictures and produced drawings of those pieces of furniture. The researchers used machine learning to discover similar patterns of brain activity across both tasks within the occipital cortex, an area of the brain important for visual processing. This means people recruit the same neural representation of an object whether they are drawing it or seeing it.

As the participants drew each object multiple times, the activity patterns in occipital cortex remained unchanged, but the connection between occipital cortex and parietal cortex, an area involved in motor planning, grew more distinct. This suggests that drawing practice enhances how the brain shares information about an object between different regions over time.

The (neuro)science of getting and staying motivated

There is no question that motivation is one of the hardest and yet important factors in life. It’s the difference between success and failure, goal-setting and aimlessness, well-being and unhappiness. And yet, why is it so hard to get motivated – or even if we do, to keep it up?

That is the question that scientists led by Professor Carmen Sandi at EPFL and Dr Gedi Luksys at the University of Edinburgh have sought to answer. The researchers worked off previous knowledge that told them two things: First, that people differ a lot in their capacity to engage in motivated behavior and that motivational problems like apathy are common in neurodegenerative and psychiatric disorders. Second, to target an area of the brain called the “nucleus accumbens”.

Sitting close to the bottom of brain, the nucleus accumbens has been the subject of a lot of research. The reason is that it was quickly found to be a major player in functions like aversion, reward, reinforcement, and motivation.

To test and quantify motivation, the EPFL team designed what is known as a “monetary incentive force task”. The idea is that participants perform a task with increasing – and measurable – effort and get paid sums of money that correspond to their effort. Basically, do more and get paid more.

In this study, 43 men were scanned to measure–metabolites in the nucleus accumbens in their brains with a sophisticated brain-imaging technique called “proton magnetic resonance spectroscopy”, or 1H-MRS. This can specifically measure the abundance of neurochemicals in the brain, such as neurotransmitters and metabolites. Because of this 1H-MRS is used even in clinical settings to determine neurological disorders.

Subsequently, each participant was asked to squeeze a device that measures force – a dynamometer – to a given level of contraction in order to earn either 0.2, 0.5, or 1 Swiss franc. This procedure was repeated for a number of 120 consecutive trials, which made performance in the task quite demanding.

The idea of the experiment was that the different sums would push participants to decide if they were going to invest energy and perform the task accordingly at each trial. The scientists also ran the experiment under isolation and group conditions to investigate the influence of competition on performance.

Once they had gathered the behavioral data, the researchers processed it through a computational model that estimated the most appropriate parameters that should be measured with regard to utility, effort, and performance functions. This allowed them to interrogate whether particular neurotransmitter levels predicted specific motivational functions.

The analysis revealed that the key to performance – and, by extension, motivation – lies within the ratio of two neurotransmitters in the nucleus accumbens: glutamine and glutamate. Specifically, the ratio of glutamine to glutamate relates to our capacity for maintaining performance over a long period of time – what the researchers term “stamina”.

Another discovery was that competition seems to boost performance even from the beginning of the task. This was especially the case for individuals with low glutamine-to-glutamate ratios in the nucleus accumbens.

“The findings provide novel insights in the field of motivation neuroscience,” says Carmen Sandi. “They show that the balance between glutamine and glutamate can help predict specific, computational components of motivated performance. Our approach and data can also help us develop therapeutic strategies, including nutritional interventions, that address deficits in effort engagement by targeting metabolism.”

Now I can’t unhear Marvin the Martian whenever RJ speaks. Thanks for that, lmao

Look, I love the changes in art style over time, but I will never forgive Morrison for going from ‘RJ’s face is always shrouded in shadow’ to ‘RJ is Marvin the martian’

Neat!

Crocodile or alligator? Neither! It’s the Yacaré caiman (Caiman yacare), a close relative of the alligator. This South American species can be found in wetland habitats in parts of Argentina, Brazil, and Paraguay where it feeds on fishes, including the fearsome piranha. However intimidating that may be, this up to 10-foot (3-meter)-long animal is still not at the top of the food chain. Powerful predators like jaguars and large snakes prey on the Yacaré caiman. Photo: Bernard DUPONT, CC BY-SA 2.0, flickr https://www.instagram.com/p/CGjL5FgARF9/?igshid=1ccrpr7grzr0v

Exploring the Marvels of Biological Macromolecules: The Molecular Machinery of Life (Part 3)

Proteins and Enzymes: Catalysts of Molecular Reactions

Proteins are the central players in macromolecular interactions. Enzymes, a specialized class of proteins, catalyze biochemical reactions with remarkable specificity. They bind to substrates, facilitate reactions, and release products, ensuring that cellular processes occur with precision.

Protein-Protein Interactions: Orchestrating Cellular Functions

Proteins often interact with other proteins to form dynamic complexes. These interactions are pivotal in processes such as signal transduction, where cascades of protein-protein interactions transmit signals within cells, regulating diverse functions such as growth, metabolism, and immune responses.

Protein-Ligand Interactions: Molecular Recognition

Proteins can also interact with small molecules called ligands. Receptor proteins, for instance, bind to ligands such as hormones, neurotransmitters, or drugs, initiating cellular responses. These interactions rely on specific binding sites and molecular recognition.

Protein-DNA Interactions: Controlling Genetic Information

Transcription factors, a class of proteins, interact with DNA to regulate gene expression. They bind to specific DNA sequences, promoting or inhibiting transcription, thereby controlling RNA and protein synthesis.

Membrane Proteins: Regulating Cellular Transport

Integral membrane proteins participate in macromolecular interactions by regulating the transport of ions and molecules across cell membranes. Transport proteins, ion channels, and pumps interact precisely to maintain cellular homeostasis.

Cooperativity and Allosteric Regulation: Fine-Tuning Cellular Processes

Cooperativity and allosteric regulation are mechanisms that modulate protein function. In cooperativity, binding one ligand to a protein influences the binding of subsequent ligands, often amplifying the response. Allosteric regulation occurs when a molecule binds to a site other than the active site, altering the protein's conformation and activity.

Interactions in Signaling Pathways: Cellular Communication

Signal transduction pathways rely on cascades of macromolecular interactions to transmit extracellular signals into cellular responses. Kinases and phosphatases, enzymes that add or remove phosphate groups, play pivotal roles in these pathways.

Protein Folding and Misfolding: Disease Implications

Proteins must fold into specific three-dimensional shapes to function correctly. Misfolded proteins can lead to Alzheimer's, Parkinson's, and prion diseases. Chaperone proteins assist in proper protein folding and prevent aggregation.

References

Voet, D., Voet, J. G., & Pratt, C. W. (2016). Fundamentals of Biochemistry: Life at the Molecular Level. Wiley.

Lehninger, A. L., Nelson, D. L., & Cox, M. M. (2017). Lehninger Principles of Biochemistry. W. H. Freeman.

Berg, J. M., Tymoczko, J. L., & Stryer, L. (2002). Biochemistry. W. H. Freeman

Reblog if you write fanfic and would be totally down with your followers coming into you askbox and talking to you about your fic

I think everybody needs to see this hilarious little thing that was posted to the official Puss in Boots tiktok. It's a parody of that one Old Spice commercial.

These are really neat lizards!

FIVE BANDED GLIDING LIZARD Draco quinquefasciatus

Draco is a genus of agamid lizards that are also known as flying lizards, flying dragons or gliding lizards. These lizards are capable of gliding flight; their ribs and their connecting membrane may be extended to create “wings” (patagia- similar to flying squirrels), the hindlimbs are flattened and wing-like in cross-section, and a flap on the neck (the gular flag) serves as a horizontal stabilizer (the flag is sometimes used in warning to others).

Draco are arboreal insectivores.

While not capable of powered flight they often obtain lift in the course of their gliding flights. Glides as long as 60 m (200 ft) have been recorded, over which the animal loses only 10 m (33 ft) in height, which is quite some distance, considering that these lizards are only around 20 cm (7.9 in) in total length (tail included).

They are found in South Asia and Southeast Asia, and are fairly common in forests, gardens, teak plantations and shrub jungle.

Below showing wings and gular flag. ©A.S.Kono Sulawesi Lined Gliding Lizard Draco spilonotus

I mean sure, I’m really terrible at actually getting stuff out but questions/ critique are always welcome!

Reblog if you write fanfic and would be totally down with your followers coming into you askbox and talking to you about your fic